Effects of L-Asparaginase on Lymphocyte Surface and Blastogenesis1
نویسندگان
چکیده
L-Asparaginase is immunosuppressive, inhibiting both the cellular and humoral responses, as well as the concanavalin Aand/or phytohemagglutinin-induced blastogenesis of lymphocytes. However, its mechanism of action is presently unclear. This study dealt with the enzyme effects on the lymphocyte surface leading to interference with the binding of concanavalin A. The mitogen was labeled with ' 25I and added
منابع مشابه
Effects of L-asparaginase on lymphocyte surface and blastogenesis.
SUMMARY L-Asparaginase is immunosuppressive, inhibiting both the cellular and humoral responses, as well as the concanavalin A-and/or phytohemagglutinin-induced blastogenesis of lymphocytes. However, its mechanism of action is presently unclear. This study dealt with the enzyme effects on the lymphocyte surface leading to interference with the binding of concanavalin A. The mitogen was labeled ...
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